Marijuana Eases Spasticity in MS PatientsStudies Show Marijuana Extracts May Have Therapeutic Value for Multiple Sclerosis SymptomsBy Bill HendrickWebMD Health NewsReviewed by Louise Chang, MDDec. 4, 2009 -- Marijuana extracts may reduce spasticity symptoms in people with multiple sclerosis, a new study shows.The review, by Shaheen Lakhan, PhD, and Marie Rowland, PhD, of the Global Neuroscience Initiative Foundation in Los Angeles, found that five of six published studies they analyzed reported a reduction in spasticity and an improvement in mobility in MS patients treated with marijuana extracts.Lakhan tells WebMD in an email that the extracts were administered orally. The reviewed studies included the use of cannabis extracts delta9-tetrahydrocannabinol, or THC, and cannabidiol, or CBD, in people with MS."We found evidence that combined THC and CBD extracts may provide therapeutic benefit for MS spasticity symptoms," Lakhan says in a news release.Involuntary muscle spasms (spasticity) are common symptoms of MS. The researchers say that many existing therapies for this condition are difficult to obtain, ineffective, or associated with intolerable side effects.Side effects varied greatly and depended on the amount needed to limit spasticity, the researchers write. However, side effects also were seen in people in placebo groups."Considering the distress and limitations spasticity brings to individuals with MS, it is important to carefully weigh the potential for side effects with the potential for symptom relief, they say in the news release.Lakhan says the therapeutic potential of cannabinoids in MS "is comprehensive and should be given considerable attention."In the paper, published in the open access journal BMC Neurology, the researchers write that recently introduced therapies of combined THC and CBD have the potential to relieve symptoms and that past reviews have suggested that cannabinoid therapy is beneficial for people with MS.Generally, use of the marijuana extracts were well-tolerated in patients, the researchers write."We found evidence that combined THC and CBD extracts may provide therapeutic benefit for MS spasticity symptoms. Although some objective measures of spasticity noted improvement trends, there were no changes found to be significant in post-treatment assessments."But subjective assessment of relief of spasticity suggested significant improvement after treatment, they write.The reviewed studies were published between 2002 and 2007 and included data from nearly 500 people with MS. Five of the six studies analyzed reported significant improvements in spasticity; one study reported no improvement in spasticity. Posted byNorthern Lights Medical Montana Marijuanaat0 comments Thursday, January 28, 2010 Link to website for medical marijuana in Montanahttp://www.montana-medicalmarijuana.com/Posted byNorthern Lights Medical Montana Marijuanaat0 comments Parkinson's Disease News Parkinson's disease patients who have tried marijuana say the drug helped relieve their symptoms.Dr. Evzin Ruzicka, an attending neurologist at Charles University in Prague in the Czech Republic, reported the findings here at the Movement Disorders Society's Seventh International Congress of Parkinson's Disease and Movement Disorders. Ruzicka is also a consultant at the Prague Movement Disorders Center. "It's difficult to directly study the medical effects of cannabis in the Czech Republic, where we conducted our research, because of its illegal status," Ruzicka told Reuters Health. "Therefore, we had to conduct anonymous surveys. To our knowledge, this is the first study to assess the effect of cannabis on Parkinson's disease, and our findings suggest it may alleviate some symptoms." Ruzicka and his colleagues chose to investigate marijuana's effects on Parkinson's disease after hearing from several patients that they had tried the drug and it had helped them. The investigators asked all patients who were treated for Parkinson's disease at their center to complete a questionnaire that asked about cannabis use and about several Parkinson's disease symptoms, including overall symptoms; tremor while at rest; bradykinesia, or slow movement; muscle rigidity; and dyskinesias, or involuntary movements. Dyskinesias are caused by levodopa, the mainstay medication in Parkinson's treatment. Among the 630 patients to whom the investigators sent questionnaires, 339 (54%) returned them. The responders' average age was about 66, and they had had Parkinson's disease for an average of roughly 9 years. Among the responders, 25% reported that they had used cannabis. Most had used it orally, either as fresh or dried leaves. Within this group, 39 patients (46%) reported that their Parkinson's disease symptoms in general were relieved after they started using cannabis. In terms of specific symptoms, 26 (31%) reported an improvement in tremor while at rest, and 38 (45%) experienced a relief of bradykinesia. Relief of muscle rigidity was reported by 32 (38%), and 12 (14%) said they had an improvement in levodopa-induced dyskinesias. The respondents reported that the improvement in symptoms occurred an average of 1.7 months after they had started using cannabis. Patients who used it for at least three months were more likely to experience symptom relief than those with shorter experience, the investigators reported. This delay between the beginning of cannabis use and the relief of symptoms made it unlikely that the respondents were having a placebo effect, Ruzicka said. A placebo effect can occur when the individual taking a treatment experiences a benefit even if the "treatment," such as a sugar pill, contains no active ingredients. They found no relationship between the length of cannabis use and the effect on involuntary movements. However, daily marijuana users reported more improvement in their dyskinesias than those using it less often. The investigators speculated that the effect of cannabis on Parkinson's disease symptoms may be due to interaction among cannabis, certain brain receptors that respond to cannabis and endogenous cannabinoids or cannabis-like substances within the body. He and colleagues plan to investigate a relationship between cannabis use and relief of Parkinson's disease symptoms by collaborating in further studies with investigators in the United Kingdom, Ruzicka told Reuters Health.
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